Influenza neuraminidases are glycoproteins that facilitate the transmission of the influenza virus from cell to cell. Zanamivir is a widely used neuraminidase inhibitor. In Simulated Docking of Zanamivir with the 2009 Pandemic Strain Influenza A/H1N1 Neuraminidase Active Site , I provide a computational docking analysis of zanamivir with the active site of the neuraminidase of the 2009 Influenza A/H1N1 strain. The computed inhibitor/receptor binding energy suggests that zanamivir would be only marginally effective against that strain.
Simulated Docking of Oseltamivir with the 1918 Pandemic Strain Influenza A/H1N1 Neuraminidase Active Site argues that oseltamivir (Tamiflu(R)) would not have been effective against the 1918 pandemic Influenza A/H1N1 strain.